Bad wrap: Myelin and myelin plasticity in health and disease
نویسندگان
چکیده
منابع مشابه
Myelin plasticity and behaviour — connecting the dots
Myelin sheaths in the vertebrate nervous system enable faster impulse propagation, while myelinating glia provide vital support to axons. Once considered a static insulator, converging evidence now suggests that myelin in the central nervous system can be dynamically regulated by neuronal activity and continues to participate in nervous system plasticity beyond development. While the link betwe...
متن کاملMyelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat.
The unlabeled peroxidase-antiperoxidase method has been used with antiserum against "myelin-associated glycoprotein" to establish the presence of the glycoprotein in myelin and myelin-forming cells of the developing rat nervous system. Myelin-associated glycoprotein is found in oligodendroglial cytoplasm before the beginning of myelination. Staining intensity of oligodendroglia increases during...
متن کاملMyelin instability and oligodendrocyte metabolism in myelin-deficient mutant mice
During the active phase of myelination in myelin-deficient mutant mice (mld), myelin basic protein (MBP) synthesis is defective and the myelin lamellae are uncompacted. In these mutants, we found a fast metabolism of the myelin-associated glycoprotein (MAG) and of sulfatides, and the presence of cholesterol esters and a degradation product of MAG, dMAG, indicating that mld myelin was unstable. ...
متن کاملSerum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker
Objective: Multiple sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As myelin basic protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 health...
متن کاملSynthesis Myelin and Incorporation of Myelin Polypeptides into CNS
The distribution of newly synthesized proteolipid protein (PLP, 23 kdaltons) and myelin basic proteins (MBPs, 14-21.5 kdaltons) was determined in microsomal and myelin fractions prepared from the brainstems oi 10-30 d-old rats sacrificed at different times after an intracranial injection of 3~S-methionine. Labeled MBPs were found in the myelin fraction 2 min after the injection, whereas PLP app...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Neurobiology
سال: 2017
ISSN: 1932-8451
DOI: 10.1002/dneu.22541